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Your PRODIGY prediction (ExampleProdigy) has finished successfully.

Please note that the results will be deleted after two weeks.

To cite PRODIGY, please refer to:

  1. Vangone A. and Bonvin A.M.J.J. "Contact-based prediction of binding affinity in protein-protein complexes", eLife, 4, e07454 (2015).
  2. Xue L., Rodrigues J., Kastritis P., Bonvin A.M.J.J.*, Vangone A.*, "PRODIGY: a web-server for predicting the binding affinity in protein-protein complexes", Bioinformatics, doi:10.1093/bioinformatics/btw514 (2016).

For more information about the predictive model please check the PRODIGY prediction method page.

Further information can be found in the PRODIGY Manual and an example of the PRODIGY output can be found here.

Back to PRODIGY home page

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Binding affinity and Kd prediction

The binding affinity (ΔG) and dissociation constant (Kd)predicted values are:
Protein-protein complexΔG (kcal mol-1)Kd (M) at 25.0 ℃
1e6j -9.1 2.1E-07

Prediction details

Number of Interfacial Contacts (ICs) per property:
ICs charged-charged:0
ICs charged-polar:7
ICs charged-apolar:8
ICs polar-polar:5
ICs polar-apolar:15
ICs apolar-apolar:26
Non Interacting Surface (NIS) per property:
NIS charged: 20.48%
NIS apolar: 38.77%
Table of the ICs at the interface:
List of residue-residue pairs at the interface (.txt)

Download outputs

Pymol ICs-based representation script (.pml)
Archive file of all the outputs (.tgz)
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This work is co-funded by the Horizon 2020 projects EOSC-hub and EGI-ACE (grant numbers 777536 and 101017567), BioExcel (grant numbers 823830 and 675728)
and by a computing grant from NWO-ENW (project number 2019.053).