Run gQH_3T7grzrD
Status: FINISHED
Your DisVis run has successfully completed.
Please cite the following papers in your work:
- R.V. Honorato, P.I. Koukos, B. Jimenez-Garcia, A. Tsaregorodtsev, M. Verlato, A. Giachetti, A. Rosato and A.M.J.J. Bonvin (2021). Structural biology in the clouds: The WeNMR-EOSC Ecosystem. Frontiers Mol. Biosci., 8, fmolb.2021.729513.
- G.C.P. van Zundert, M. Trellet, J. Schaarschmidt, Z. Kurkcuoglu, M. David, M. Verlato, A. Rosato and A.M.J.J. Bonvin (2016)
The DisVis and PowerFit web servers: Explorative and Integrative
Modeling of Biomolecular Complexes.
J. Mol. Biol., Advanced Online Publication. - G.C.P. van Zundert and A.M.J.J. Bonvin (2015) DisVis: Quantifying and visualizing accessible interaction space of distance-restrained biomolecular complexes." Bioinformatics 31, 3222-3224.
and add the following acknowledgment:
The FP7 WeNMR (project# 261572), H2020 West-Life (project# 675858), the EOSC-hub (project# 777536) and the EGI-ACE (project# 101017567) European e-Infrastructure projects are acknowledged for the use of their web portals, which make use of the EGI infrastructure with the dedicated support of CESNET-MCC, INFN-LNL-2, NCG-INGRID-PT, TW-NCHC, CESGA, IFCA-LCG2, UA-BITP, TR-FC1-ULAKBIM, CSTCLOUD-EGI, IN2P3-CPPM, CIRMMP, SURFsara and NIKHEF, and the additional support of the national GRID Initiatives of Belgium, France, Italy, Germany, the Netherlands, Poland, Portugal, Spain, UK, Taiwan and the US Open Science Grid.
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Accessible Interaction Space
The accessible interaction space consistent with at least N restraints is depicted below. Use the slider to adjust N and the arrows on the side of the images to change the view.
Current Level (N): 2
Images were generated with UCSF Chimera.
Accessible Complexes
The table below lists the number of complexes consistent with at least N restraints as raw number and as fraction of all complexes.
| Number of consistent restraints (N) | Number of accessible complexes consistent with at least N restraints | Fraction of accessible complexes consistent with at least N restraints |
|---|---|---|
| 0 | 690155902 | 100.00 % |
| 1 | 17982987 | 2.61 % |
| 2 | 2902126 | 0.42 % |
| 3 | 67256 | 0.01 % |
| 4 | 1296 | 0.00 % |
| 5 | 0 | 0.00 % |
z-Score
The table below features the z-Score for each restraint. The higher the score, the more likely the restraint is a false-positive. Z-scores above 1.0 are explicitly mentioned in the output of DisVis.
| # | Restraint | Average violated fraction | Standard deviation | Z-score |
|---|---|---|---|---|
| 1 | A40(CA)-B252(CA) | 0.69 | 0.20 | 0.11 |
| 2 | A90(CA)-B176(CA) | 0.84 | 0.20 | 1.57 |
| 3 | A135(CA)-B158(CA) | 0.58 | 0.11 | -1.01 |
| 4 | A161(CA)-B132(CA) | 0.61 | 0.16 | -0.69 |
| 5 | A252(CA)-B40(CA) | 0.70 | 0.19 | 0.16 |
| 6 | A176(CA)-B90(CA) | 0.84 | 0.20 | 1.58 |
| 7 | A158(CA)-B135(CA) | 0.58 | 0.11 | -1.00 |
| 8 | A132(CA)-B161(CA) | 0.61 | 0.16 | -0.71 |
Violations
The table below shows how often a specific restraint is violated for complexes consistent with a number of restraints. The higher the violation fraction of a specific restraint, the more likely it is to be a false-positive. Column 1 shows the number of consistent restraints N, while each following column indicates the violation fractions of a specific restraint for complexes consistent with at least N restraints. Each row thus represents the fraction of all complexes consistent with at least N restraints that violated a particular restraint.
| Number of consistent restraints (N) | Restraint 1 | Restraint 2 | Restraint 3 | Restraint 4 | Restraint 5 | Restraint 6 | Restraint 7 | Restraint 8 |
|---|---|---|---|---|---|---|---|---|
| 1 | 0.85 | 0.92 | 0.77 | 0.88 | 0.85 | 0.92 | 0.76 | 0.88 |
| 2 | 0.92 | 0.94 | 0.56 | 0.56 | 0.93 | 0.94 | 0.56 | 0.56 |
| 3 | 0.50 | 0.98 | 0.50 | 0.51 | 0.51 | 0.98 | 0.51 | 0.50 |
| 4 | 0.50 | 0.50 | 0.50 | 0.50 | 0.50 | 0.50 | 0.50 | 0.50 |
