Welcome to the Utrecht Biomolecular Interaction Web Portal >>


PRODIGY (PROtein binDIng enerGY prediction) is a collection of web services focused on the prediction of binding affinity in biological complexes as well as the identification of biological interfaces from crystallographic one.

  • To predict the binding affinity in PROTEIN-PROTEIN complexes, please visit the PRODIGY page.
  • To predict the binding affinity in PROTEIN-SMALL LIGAND complexes, please visit the PRODIGY-LIG page.
  • To classify interfaces between biological or crystallographic, please visit the PRODIGY-CRYSTAL page.
Please visit the Manual page to access detailed information on the type of Input parameters needed and how to interpret the results returned by the server.

User Forum

There is a user forum dedicated to answer questions about PRODIGY server powered by the ask.bioexcel platform:
PRODIGY User Forum

GitHub Repositories

The PRODIGY web services are also available as stand alone version through Github repositories.

Browser compatibility

The following table is a summary of the PRODIGY server web browser compatibility:

OS Version Chrome Firefox Microsoft Edge Safari
Linux Ubuntu 18.04 LTS 70.0 (Chromium) 62.0 n/a n/a
MacOS HighSierra 70.0 63.0 n/a 12.0
Windows 10 71.0 63.0 42 n/a
Proudly powered by:
This work is co-funded by the Horizon 2020 projects EOSC-hub and EGI-ACE (grant numbers 777536 and 101017567), BioExcel (grant numbers 823830 and 675728)
and by a computing grant from NWO-ENW (project number 2019.053).